Jiangni Yizhong decoction combined with conventional Western medicine in the treatment of refractory gastroesophageal reflux disease
Objective To investigate the curative effect of Jiangni Yizhong decoction combined with conventional Western medicine in the patients with refractory gastroesophageal reflux disease(rGERD).Methods 134 patients with rGERD were selected and divided into the Chinese and Western medicine combination group(n=67)and conventional Western medicine group(n=67)by random number table method.The patients in the conventional Western medicine group were treated with pantoprazole and moxapride.The patients in the Chinese and Western medicine combination group were treated with Jiangni Yizhong decoction combined with pantoprazole and moxapride.The clinical efficacy,improvement of clinical symptoms,the gastrodynamic indexes,the adverse reactions,and the quality of life were compared between the two groups.Results The total effective rate in the Chinese and Western medicine combination group was 95.52%higher than 71.64%in the conventional Western medicine group,with a statistically significant difference(P<0.05).After 8 weeks of treatment,reflux disease questionnaire(RDQ)and GERD health-related quality of life scale(GERD-HRQL)scores in the Chinese and Western medicine combination group were lower than those in the conventional Western medicine group(P<0.05).After 8 weeks of treatment,the serum level of motilin in the Chinese and Western medicine combination group was higher than that in the conventional Western medicine group,the serum levels of somatostatin and vasoactive intestinal peptide(VIP)in the Chinese and Western medicine combination group were lower than those in the conventional Western medicine group(P<0.05).The total incidence of adverse reactions in the Chinese and Western medicine combination group was lower than that in the conventional Western medicine group(P<0.05).Conclusion Jiangni Yizhong decoction combined with conventional Western medicine has good clinical efficacy in the treatment of rGERD patients,which can effectively alleviate clinical symptoms,improve the gastric dynamics,reduce the occurrence of adverse reactions,improve the quality of life.
万方数据
维普
