Effects of Qishen Yiqi Guttate pills combined with metoprolol in the treatment of chronic congestive left heart failure
Objective To analyze the clinical effect of Qishen Yiqi Guttate pills combined with metoprolol in the treatment of chronic congestive left heart failure.Methods 99 patients were collected,and divided in the control group(metoprolol,49 cases)and the study group(Qishen Yiqi Guttate pills+metoprolol,50 cases)according to the treatment regimen.The efficacy,adverse reactions,ventricular remodeling indicators(left ventricular posterior wall diastolic thickness[LVPWd],left ventricular diastolic spherical index[LVSId],left ventricular end-systolic volume[LVESV]),calcineurin-activated T cell nuclear factor 3(CaN-NFAT3)pathway-related proteins(calcineurin[CaN],zinc finger transcription factor[GATA4],activated T cell nuclear factor 3[NFAT3]),and myocardial injury markers(creatine kinase isoenzyme[CK-MB],N-terminal pro-brain natriuretic peptide[NT-proBNP],troponin I[cTnl])were compared between the two groups.Results The total effective rate of the study group was higher than that of the control group,showing a statistically significant difference(P<0.05).After 4 weeks of treatment,LVPWd,LVSId,and LVESV in the study group were lower than those in the control group(P<0.05).After 4 weeks of treatment,CaN,GATA4,NFAT3,CK-MB,NT-proBNP,and cTnl in the study group were lower than those in the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The combination of Qishen Yiqi Guttate Pills and Metoprolol can alleviate myocardial injury and reverse ventricular remodeling in the treatment of chronic congestive left heart failure,with a reliable efficacy and good safety profile.
万方数据
维普
