Application of early heparin pretreatment in emergency treatment of acute myocardial infarction
Objective To observe the application effect of early heparin pretreatment in emergency treatment of acute myocardial infarction(AMI).Methods 115 patients with AMI were randomly divided into the routine group(57 cases)and pretreatment group(58 cases).The routine group were received emergency percutaneous coronary intervention(PCI)treatment,while the pretreatment group were received early heparin pretreatment as an adjunct to routine emergency treatment.The coronary angiography results,coronary hemodynamics,myocardial injury markers,and major adverse cardiovascular events(MACE)were compared between the two groups of patients.Results The thrombolysis rate of the pretreatment group was 89.66%higher than that of the routine group 75.44%,and the high thrombus burden rate,SRP incidence rate,and NRP incidence rate were all lower than those of the routine group(P<0.05).The SPV,DPV,and CFVR of the pretreatment group were higher than those of the routine group,while the HIR was lower than that of the routine group(P<0.05).The MYO,cTnT,CK-MB,and LDH levels in the pretreatment group were lower than those in the routine group(P<0.05).The incidence of MACE in the pretreatment group was 5.17%lower than 19.30%in the routine group,and the difference was statistically significant(P<0.05).Conclusion Early heparin pretreatment assisted emergency PCI can improve the coronary angiography results and coronary blood flow in AMI patients,and has a positive significance in reducing the risk of postoperative myocardial injury and MACE.
万方数据
维普
