摘要
静电纺丝是一种简易高效的制备连续纳米级至微米级纤维的技术.壳聚糖是自然界中唯一存在的碱性阳离子多糖,静电纺丝法制备的壳聚糖基纳米纤维具有比表面积大、孔隙率高、给药能力强、生物相容性好、生物降解性好、止血、抗菌、促愈合等优点,在组织工程领域具有广阔的应用前景.本文综述了壳聚糖基静电纺丝纳米纤维的制备及其在骨、皮肤、血管和神经组织工程领域的研究进展,对其在组织工程领域未来的发展方向进行展望,以期为后续研究提供理论参考.
Abstract
Electrospinning is a simple and efficient technology used to prepare continuous nano or microfibers.Chitosan is the only natural alkaline cationic polysaccharide.Chitosan-based nanofibers prepared through electro-spinning have the advantages of large specific surface area,high porosity,strong drug delivery ability,good bio-compatibility,good biodegradability,hemostasis,antibacterial ability,and healing promotion ability.Hence,they have broad application prospects in the field of tissue engineering.The preparation of chitosan-based electrospin-ning nanofibers and research advances of such nanofibers in bone,skin,blood vessels,and nerve tissue engineering have been reviewed.Finally,we present the future development direction of chitosan-based electrospinning nano-fibers in tissue engineering and expect to provide a theoretical reference for future research.
国家科技期刊平台
NSTL
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