A chitosan-based antibacterial hydrogel with injectable and self-healing capabilities

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外文摘要：The presence of bacteria directly affects wound healing.Chitosan-based hydrogel biomaterials are a solution as they offer advantages for wound-healing applications due to their strong antimicrobial properties.Here,a double-cross-linking chitosan-based hydrogel with antibacterial,self-healing,and injectable properties is reported.Thiolated chitosan was successfully prepared,and the thiolated chitosan molecules were cross-linked by Ag-S coordination to form a supramolecular hydrogel.Subsequently,the amine groups in the thiolated chitosan covalently cross-linked with genipin to further promote hydrogel formation.In vitro experimental results indicate that hydrogel can release Ag+over an extended time,achieving an antibac-terial rate of over 99％against Escherichia coli and Staphylococcus aureus.Due to the reversible and dynamic feature of Ag-S coordination,an antibacterial hydrogel exhibited injectable and self-healing capabilities.Additionally,the hydrogel showed excellent biocompatibility and biodegradability.

外文关键词：

HydrogelChitosanSilver ionCross-linkingAntibacterial

作者：

Rui Chen、Yanan Hao、Secundo Francesco、Xiangzhao Mao、Wen-Can Huang

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作者单位：

State Key Laboratory of Marine Food Processing and Safety Control,College of Food Science and Engineering,Ocean University of China,Qingdao 266404,China

Qingdao Key Laboratory of Food Biotechnology,Qingdao 266404,China

Key Laboratory of Biological Processing of Aquatic Products,China National Light Industry,Qingdao 266404,China

Istituto di Scienze e Tecnologie Chimiche"Giulio Natta",Consiglio Nazionale delle Ricerche,Via Mario Bianco 9,20131 Milan,Italy

Laboratory for Marine Drugs and Bioproducts of Qingdao National Laboratory for Marine Science and Technology,Qingdao 266237,China

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出版年：

2024

DOI：

10.1007/s42995-023-00211-z

海洋生命科学与技术(英文)

ISSN：

年,卷(期)：2024.6(1)