Role of marine natural products in the development of antiviral agents against SARS-CoV-2:potential and prospects

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外文摘要：A novel coronavirus,known as severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),has surfaced and caused global concern owing to its ferocity.SARS-CoV-2 is the causative agent of coronavirus disease 2019;however,it was only discovered at the end of the year and was considered a pandemic by the World Health Organization.Therefore,the develop-ment of novel potent inhibitors against SARS-CoV-2 and future outbreaks is urgently required.Numerous naturally occurring bioactive substances have been studied in the clinical setting for diverse disorders.The intricate infection and replication mechanism of SARS-CoV-2 offers diverse therapeutic drug targets for developing antiviral medicines by employing natural products that are safer than synthetic compounds.Marine natural products(MNPs)have received increased attention in the development of novel drugs owing to their high diversity and availability.Therefore,this review article investigates the infection and replication mechanisms,including the function of the SARS-CoV-2 genome and structure.Furthermore,we highlighted anti-SARS-CoV-2 therapeutic intervention efforts utilizing MNPs and predicted SARS-CoV-2 inhibitor design.

外文关键词：

SARS-CoV-2Marine natural productsDrug targetsInhibitors

作者：

D.P.Nagahawatta、N.M.Liyanage、Thilina U.Jayawardena、H.H.A.C.K.Jayawardhana、Seong-Hun Jeong、Hyung-Jun Kwon、You-Jin Jeon

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作者单位：

Department of Marine Life Sciences,Jeju National University,Jeju 690-756,Republic of Korea

Department of Chemistry,Biochemistry and Physics,Université du Québec à Trois-Rivières,Trois-Rivières,QC G8Z 4M3,Canada

Functional Biomaterial Research Center,Korea Research Institute of Bioscience and Biotechnology,Jeongeup-si,Republic of Korea

Marine Science Institute,Jeju National University,Jeju 63333,Republic of Korea

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出版年：

2024

DOI：

10.1007/s42995-023-00215-9

海洋生命科学与技术(英文)

ISSN：

年,卷(期)：2024.6(2)