儿童艰难梭菌感染研究进展
Research progress of Clostridioides difficile infection in children
姜亚军 1白璐璐 2张文竹 2李颖 3徐特龙 2何国忠 4卢金星 2吴媛 2张必科2
作者信息
- 1. 中国疾病预防控制中心,北京 102206
- 2. 传染病溯源预警与智能决策全国重点实验室,中国疾病预防控制中心传染病预防控制所,北京 102206
- 3. 传染病溯源预警与智能决策全国重点实验室,中国疾病预防控制中心传染病预防控制所,北京 102206;中国海洋大学食品科学与技术学院,山东青岛 266003
- 4. 昆明医科大学公共卫生学院,云南昆明 650000
- 折叠
摘要
艰难梭菌是抗生素相关性腹泻最常见的一种致病菌,也是全世界范围内最常见的医疗机构相关感染,特别是作为伪膜性肠炎等相关疾病的重要病原体,受到越来越多的临床关注.随着儿童艰难梭菌高感染率的广泛报告,给医疗系统带来持续负担,因此,开展儿童艰难梭菌感染的监测工作尤为重要.本研究就艰难梭菌在儿童中的定植、感染、分子流行病学特征及其影响因素、诊断治疗等方面进行了归纳汇总,旨在总结儿童艰难梭菌感染相关的研究进展,为开展持续监测和改进儿童艰难梭菌防控策略提供参考.
Abstract
Clostridioides difficile is one of the most common pathogens of antibiotic-associated diarrhea,and the most common healthcare-associated infections worldwide,especially associated diseases such as pseudomembranous enteritis.It is receiving increasing clinical attention.With high rates of C.difficile infection in children widely reported,there is an ongoing burden on the healthcare system.Therefore,surveillance for C.difficile infection in children is particularly important.This article summarizes the colonization,infection,molecular epidemiological characteristics,influencing factors,diagnosis and treatment of C.difficile in children,aiming to summarize the research progress related to C.difficile in children and to provide reference for the development of continuous surveillance and improvement of C.difficile prevention and control strategies in children.
关键词
艰难梭菌/儿童/感染/定植/分子流行病学/诊疗Key words
Clostridioides difficile/Children/Infection/Colonization/Molecular epidemiology/Diagnosis and treatment引用本文复制引用
基金项目
教育部哲学社会科学研究重大课题攻关项目(21JZD039)
重点研发计划项目(2021YFC2600501)
重点研发计划项目(2023YFC2308801)
出版年
2024
NETL
NSTL
万方数据