Influence of immunization schedule adjustment on mumps antibody level in healthy population based on an immunity level surveillance results in Hunan,2020-2022
Objective To understand the influence of immunization schedule adjustment on mumps antibody level in healthy population in Hunan province and provide evidence for the evaluation of short-term immunization effect of 2-dose mumps containing vaccine(MuCV).Methods A mumps immunity level surveillance in healthy population was conducted in Hunan from January 2020 to December 2022.In local children aged 1-3 years,those who got 2 dose MuCV vaccination after immunization schedule adjustment were selected as 2-dose group and those who only got 1 dose MuCV vaccination were selected as 1-dose group.The positive rate and geometric mean concentration(GMC)of mumps IgG in two groups were calculated and compared.Results A total of 169 study subjects were included,including 73 in 2-dose group and 96 in 1-dose group.There was no significant difference in gender,age,and interval from last MuCV vaccination between two groups(x2=0.002,P=0.963;x2=3.618,P=0.164;x2=0.757,P=0.685).The positive rate of mumps IgG was higher in 2-dose group(98.63％)than in 1-dose group(81.65％)(x2=12.553,P＜0.05).The GMC of mumps IgG was higher in 2-dose group(928.48 IU/mL)than in 1-dose group(265.89 IU/mL)(H=47.659,P＜0.05).Conclusions The positive rate and GMC of mumps IgG increased in 1-3 years-old healthy population after the implementation of 2-dose MuCV vaccination in Hunan,and the GMC of IgG showed no obvious decline in the observation period,but the influences of immunization schedule adjustment on long-term immunity persistence and reduction of mumps cases need to be further observed.
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