摘要
大鼠血管性痴呆2-VO造模法是国内外学者研究血管性痴呆(vascular dementia,VD)最常选用的造模方法,该方法具有重复性好、便于操作、评价指标严格的优点,但同时2-VO造模法也存在与临床发病机理仍有差距等不足之处.大鼠血管性痴呆2-VO造模法优化方案常见2-VO+操作方式改良法、2-VO+硝普钠造模法、2-VO+其他致病因素造模法等.对于构建成模的大鼠血管性痴呆模型评价方法主要集中在行为学、组织形态学、影像学、血液生化及相关指标等方面.本研究对上述各种大鼠血管性痴呆2-VO模型法优化方案的构建方法、优势、不足进行了总结,同时对VD模型的评价方法进行了概述,以期为今后的实验研究提供参考.
Abstract
The 2-VO modeling method for vascular dementia in rats is the most commonly used modeling method for VD studies at home and abroad.This method has the advantages of good repeatability,easy operation and strict evaluation indicators,but at the same time,the 2-VO modeling method still has shortcomings such as gaps with clinical pathogenesis.The optimal meth-ods of 2-VO modeling for vascular dementia in rats include 2-VO+improved operation mode,2-VO+sodium nitroprusside mod-eling,2-VO+other pathogenic factors modeling,etc.The evaluation methods of the constructed rat vascular dementia model mainly focus on the aspects of behavior,histomorphology,imaging,blood biochemistry and related indexes.In this paper,the con-struction methods,advantages and disadvantages of the above-mentioned 2-VO model optimization schemes for rat vascular de-mentia were summarized,and the evaluation methods of VD model were summarized,in order to provide reference for future ex-perimental studies.
基金项目
内蒙古自治区自然科学基金(2021MS08088)
内蒙古自治区科技攻关计划(2021GG0193)
内蒙古教育厅研究生项目(YKD2023ZY001)
内蒙古教育厅科创项目(B20231120Z)
维普
万方数据