Anti-inflammatory Activity Research of the Ethyl Acetate Extracts From Amomum paratsao-ko
Objective To study the anti-inflammatory activity of ethyl acetate extracts from Amomum paratsao-ko and its mechanism.Methods The increasing in celiac vascular permeability caused by acetic acid,rat carboxymethyl cellulose (CMC) model,the weight of cotton granuloma in mice and carrageenan-induced hind paw edema model were employed to evaluate the anti-inflammatory activity of ethyl acetate extracts from Amomum paratsao-ko.Ultraviolet spectrophotometry and enzyme-linked immunosorbent assay were used for the detection of prostaglandin E2 (PGE2),tumor necrosis factor α (TNF-α),interleukin-1 β (IL-1β),nitric oxide (NO) and malondialdehyde (MDA).Result The ethyl acetate extracts from Amomum paratsao-ko significantly decreased the capillary hyperpermeabitity in mice,inhibited the migration of white blood cell in CMC capsule,reduced granuloma formation in mice,relieved the carrageenan-induced hind paw edema,decreased the secretion of inflammatory mediators PGE2,IL-1β and TNF-α,and reduced the accumulation of NO and MDA in vivo.Conclusion The ethyl acetate extracts from Amomum paratsao-ko had obvious anti-inflammatory activity,which may be related to the inhibition on inflammatory factors and the reduction of peroxidation products.
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