Effect of Monotropein on Osteoporosis Induced by Bilateral Ovariectomy in Rats
Objective To investigate the effect of monotropein,an extract of Morinda officinalis on postmenopausal osteoporosis model.Methods SD rats were randomly divided into normal group,model group,E2 group,monotropein group and Morinda officinalis group.The postmenopausal osteoporosis model was established by bilateral gonadectomy,and the administration groups were given monotropein and Morinda officinalis by intragastric administration.After 12 weeks of administration,the rats were dissected,and the serum biochemical indices,femoral morphology and related indices were determined.Results Compared with normal group,serum levels of calcium,phosphorus,alkaline phosphatase,osteocalcin and osteogenesis specific transcription factors were increased,the number of bone trabecular,bone volume fraction,bone surface area and bone volume ratio,bone trabecular thickness were decreased,and the separation degree of bone trabecular was increased in model group.However,after treatment with monotropein and Morinda officinalis in model rats,the serum biochemical indices(such as Ca,P,ALP,BGP and Runx2)were significantly increased as compared to the model group,and the indexes of femoral tissue and bone trabeculae in rats were significantly improved.It was further found that cymbidine and Morinda officinalis could significantly increase the levels of SOD,GSH-px and CAT,and significantly reduce the activity of MDA enzyme in serum.Conclusion Monotropein has a good effect on improving postmenopausal osteoporosis model,and its effect is similar to that of Morinda officinalis,which may be the main active ingredient of Morinda officinalis in anti-osteoporosis.
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