首页|黄芪桂枝五物汤配合活络效灵丹加减对不同分期类风湿关节炎患者的临床疗效观察

黄芪桂枝五物汤配合活络效灵丹加减对不同分期类风湿关节炎患者的临床疗效观察

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目的 观察黄芪桂枝五物汤配合活络效灵丹加减对不同分期类风湿关节炎患者临床疗效。方法 比较两组患者的基线资料、治疗前后临床症状、细胞因子水平、中医证候积分以及临床疗效。建立广义估计方程模型,比较患者临床疗效的差异。结果 治疗后两组VAS评分、压痛关节数、肿胀关节数、CRP、ESR、VEGF、IL-6、TNF-α水平和中医证候积分均降低,且观察组低于对照组。观察组治疗总有效率高于对照组。轻度活动期类风湿关节炎患者治疗4周时,观察组的临床疗效优于对照组;中度和重度活动期类风湿关节炎患者,观察组在不同时间的影响效果优于对照组。结论 黄芪桂枝五物汤配合活络效灵丹加减对不同分期类风湿关节炎患者的临床疗效具有一定的影响,在中度和重度活动期类风湿关节炎患者治疗中具有一定的优势。
Clinical Observation of Huangqi Guizhi Wuwu Tang Combined with Huoluo Xiaoling Dan on Patients with Rheumatoid Arthritis of Different Stages
Objective To observe the clinical efficacy of Huangqi Guizhi Wuwu tang combined with Huoluo Xiaoling dan in patients with rheumatoid arthritis of different stages.Methods Compared with the baseline data,clinical symptoms before and after treatment,cytokine levels,traditional Chinese medicine syndrome scores,and clinical efficacy between the two groups of patients.Established a generalized estimation equation model to compare the differences in clinical efficacy among patients.Results After treatment,VAS scores,number of tenderness joints,number of swollen joints,CRP,ESR,VEGF,IL-6,TNF-α level and traditional Chinese medicine syndrome scores decreased;the observation group was lower than the control group.The total effective rate of the observation group were higher than that of the control group.When patients with mild active rheumatoid arthritis were treated for 4 weeks,the clinical efficacy of the observation group was better than that of the control group.In patients with moderate and severe active rheumatoid arthritis,the observation group had better effects at different times than the control group.Conclusion Huangqi Guizhi Wuwu tang combined with Huoluo Xiaoling dan has a certain impact on the clinical efficacy of patients with different stages of rheumatoid arthritis,and has certain advantages in the treatment of moderate and severe active rheumatoid arthritis patients.

Huangqi Guizhi Wuwu tangHuoluo Xiaoling danrheumatoid arthritisclinical efficacy

陈甲秀、陈健、臧海珍、李代伟、许小香

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玉林市中医医院风湿病科,广西玉林 537000

黄芪桂枝五物汤 活络效灵丹 类风湿关节炎 临床疗效

2024

现代中药研究与实践
安徽中医药高等专科学校,

现代中药研究与实践

CSTPCD
影响因子:0.409
ISSN:1673-6427
年,卷(期):2024.38(2)