A Meta-analysis of Ursodeoxycholic Acid Combined with Traditional Chinese Medicine in the Clinical Treatment of Nonalcoholic Fatty Liver Disease
Objective To systematically evaluate the efficacy and safety of ursodeoxycholic acid(UDCA)combined with traditional Chinese medicine in the treatment of non-alcoholic fatty liver disease(NAFLD),and discuss its mechanism.Methods From the date of establishment of ScienceDirect,PubMed,The Cochrane Library,Web of Science,CNKI and Wanfang Data electronic databases to April 2023,the literature associated with clinical randomized controlled trials(RCTs)of UDCA combined with traditional Chinese medicine or proprietary Chinese medicine for the treatment of NAFLD was searched,then using RevMan 5.4 for meta-analysis.And summarizing the representative active components of Chinese medicine monomer and the main components of traditional Chinese patent medicines and simple preparations in the combined compound.Results 10 RCTs were included and the results of showed clinical response[OR=3.40,95％Cl(2.46,4.70),P＜0.000 01],liver function measures(AST,ALT,GGT,TBiL)were-23.50(-31.32,-15.68,P＜0.000 01),-27.67(-35.21,-20.13,P＜0.000 01),-6.85(17.93,4.22,P＜0.000 01),-3.74(-5.00,-2.49,P＜0.000 01),lipid levels(TG,TC,HDL-C,LDL-C)were-0.56(-0.76,-0.37,P＜0.000 01),-1.32(-1.63,-1.02,P＜0.000 01),0.52(0.42,0.62,P＜0.000 01),-0.49(-0.89,-0.09,P=0.02).The combination of traditional Chinese medicine includes:Bupleurum chinense DC.,Astragalus membranaceus(Fisch.)Bge.,Atractylodes macrocephala Koidz.,Salvia miltiorrhiza Bge.,Panax notoginseng(Burk.)F.H.Chen,Curcuma longa L.,Crataeguspinnatifida Bge.,Nelumbo nucifera Gaertn.,Alisma orientale(Sam.)Juzep.,Glycyrrhiza uralensis Fisch.,etc.The possible mechanisms,targets,and pathways of synergistic enhancement involve improving oxidative stress,inhibiting inflammation,regulating intestinal flora,and regulating fatty acid metabolism,etc.Conclusion The combination of UDCA and traditional Chinese medicine has a better effect on the treatment of NAFLD than UDCA alone,especially in improving liver function and blood lipid levels.
Ursodeoxycholic acidtraditional Chinese medicinenon-alcoholic fatty liver diseasenon-alcoholic steatohepatitisMeta-analysis
NETL
NSTL
万方数据
