Paeoniae Promotes Angiogenesis in OGD-mediated HUVECs Through the PGC-1α/Nrf2 Pathway
Objective To evaluate the mechanism of paeoniae on angiogenesis in oxygen-glucose deprivation(OGD)-induced injury of human umbilical vein endothelial cells(HUVECs).Methods HUVECs were randomly divided into sham group,model group,and the paeoniae containing serum group.The capacity of cell proliferation,migration,tube formation,apoptosis of HUVECs,and PGC-1α/Nrf2 protein expression methods was evaluated after paeoniae treatment,respectively.Results Paeoniae administration enhanced the capacity of cell proliferation,migration,tube formation,reduced apoptosis of HUVECs,and increased expression level of PGC-1α/Nrf2 protein(P＜0.05).Conclusion Paeoniae can reduce OGD-mediated HUVECs injury by promoting angiogenesis through the PGC-1α/Nrf2 pathway.
NETL
NSTL
万方数据
