Research Progress on Anti-depressant Mechanism of Ziziphi Semen Spinosae and its Compounds
Depression is a common and complex mental illness,which seriously affects people's health and quality of life.Ziziphi Semen Spinosae is one of the commonly used traditional Chinese medicines for the treatment of depression.A large number of clinical studies and animal experiments have confirmed that it does have a curative effect and has been widely concerned in the field of depression prevention and treatment.This paper summarizes the research results of the anti-depressant mechanism of Ziziphi Semen Spinosae,its main active ingredients and their compounds,and summarizes its anti-depressant mechanism from the aspects of regulating monoamine neurotransmitters,inflammatory cytokines and brain-derived neurotrophic factor(BDNF),so as to provide reference for the further study of the anti-depressant mechanism of Ziziphi Semen Spinosae,its main active ingredients and their compounds.
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