Clinical Observation of Compound Anti-inflammatory Ointment and its Application on Wound Management after Anal Fistula Operation
Objective To assess the clinical efficacy of a compound anti-inflammatory ointment on wound healing post-anal fistula surgery.Methods From February 2021 to February 2022,61 patients undergoing high-level complex anal fistula incision and drainage surgery were randomized into two groups.The treatment group(n=30)received topical application of the compound anti-inflammatory ointment,while the control group(n=31)used Vaseline gauze.Dressing changes commenced on the second day post-surgery.Evaluations included wound secretion,perianal edema,wound pain scores,and inflammatory markers on the 2nd and 7th days post-surgery.Results On the 2nd day post-surgery,both groups exhibited increased wound secretion scores;however,no statistically significant differences were observed(P>0.05).By the 7th day,the treatment group showed more significant improvement in wound secretion compared to the control group(P<0.05).Initial assessments of perianal edema on the 2nd day showed extensive edema in both groups,with no significant differences in edema scores(P>0.05).By the 7th day,the extent of edema had decreased in both groups,yet without significant differences between them(P>0.05).Pain levels,assessed via the Visual Analog Scale(VAS),did not differ significantly between the groups on the 2nd day(P>0.05).However,on the 7th day,pain improvement was notably better in the treatment group(P<0.05).The comparison of exudate volumes between the two groups revealed that on the 2nd day post-surgery,the treatment group recorded an exudate volume of(27.43±12.04)mL,compared to(32.74±9.87)mL in the control group.This difference was not statistically significant(P>0.05).However,on the 7th day post-surgery,the exudate volume in the treatment group was significantly reduced to(14.10±5.22)mL,whereas the control group exhibited a volume of(19.74±7.89)mL(P<0.05).This indicates a statistically significant decrease in the treatment group compared to the control group.Additionally,the application of the compound anti-inflammatory ointment demonstrated a notable improvement in the levels of inflammatory markers such as IL-6,TNF-a and IL-iβ following treatment(P<0.05).Conclusion The use of compound anti-inflammatory ointment for dressing changes following anal fistula surgery significantly reduces wound exudation,edema,and pain symptoms in patients.It also effectively inhibits the release of inflammatory factors,enhancing recovery and patient comfort post-surgery.