Research Progress on the Mechanism of Action of Curcumin Against Acute Myeloid Leukemia and Its Combination Medication
Curcumin is a class of active ingredients extracted from the rhizomes of the natural plant turmeric,which has pharmacological effects such as antitumor,immunomodulatory,and anti-inflammatory.Studies have shown that curcumin exerts anti-acute myeloid leukemia(AML)effects through a variety of mechanisms.The mechanism of action of curcumin by inhibiting cell proliferation,inducing apoptosis,immunomodulation,reversing drug resistance,inhibiting invasion and metastasis,regulating signaling pathways,and the combination of anti-AML are summarized,and the shortcomings and problems to be solved urgently are put forward,in order to provide ideas and theoretical basis for the follow-up research and clinical application of curcumin.
CurcuminAMLmechanism of actioncombination medications
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