现代中药研究与实践2024,Vol.38Issue(4) :98-102.DOI:10.13728/j.1673-6427.2024.04.017

黄酮类化合物固体分散体研究进展

Research Progress in Solid Dispersions of Flavonoids

武欣 胡晓龙 石心红 汪豪
现代中药研究与实践2024,Vol.38Issue(4) :98-102.DOI:10.13728/j.1673-6427.2024.04.017

黄酮类化合物固体分散体研究进展

Research Progress in Solid Dispersions of Flavonoids

武欣 1胡晓龙 1石心红 1汪豪1
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作者信息

  • 1. 中国药科大学 中药学院,江苏南京 210009
  • 折叠

摘要

黄酮类化合物来源广泛,活性多样,但该类化合物在水中溶解度低,生物利用度差.在多种增加黄酮类化合物溶解度的方法中,固体分散体技术因溶解度改善明显,上市药品较多,且随着新材料应用范围的拓展和新制备方法的不断突破,该技术为黄酮类化合物的开发与临床应用提供更多参考.通过查找、梳理、总结和分析国内外黄酮固体分散体的研究进展,介绍了黄酮类化合物固体分散体相关生物载体材料、制备技术和增溶机制,以期为黄酮类化合物药物发现及研究开发提供思路.

Abstract

Flavonoids have a wide range of sources and diverse activities,but these compounds have low solubility in water and poor bioavailability.In a variety of methods to increase the solubility of flavonoids,solid dispersion technology has many listed drugs due to the obvious improvement of solubility.With the expansion of the application range of new materials and the continuous breakthrough of new preparation methods,this technology provides more references for the development and clinical application of flavonoids.By finding,combing,summarizing and analyzing the research progress of flavonoid solid dispersions at home and abroad,flavonoid solid dispersions bio-carrier materials,preparation techniques and solubilization mechanisms are introduced.

关键词

黄酮/溶解度/固体分散体/增溶机制

Key words

Flavonoids/solubility/solid dispersion/solubilization mechanism

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基金项目

新疆自治区重点研发计划(2023B02010-3)

出版年

2024
现代中药研究与实践
安徽中医药高等专科学校,

现代中药研究与实践

CSTPCD
影响因子:0.409
ISSN:1673-6427
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