Effects of Platycodonis Radix on the Chemical Constituents in Shenling Baizhu San by UPLC-Q-TOF-MS/MS
Objective To explore the effect of the meridian inducing medicine Platycodonis Radix on the dissolution of chemical components in Shenling Baizhu San(SLBZS).Methods Based on the ultra-performance liquid chromatography-quadrupole-time-of-flight mass spectrometry(UPLC-Q-TOF-MS/MS)technology,the chemical composition of SLBZS,lacked Platycodonis Radix of SLBZS and Platycodonis Radix were qualitatively analyzed,and the attribution,types and relative contents were compared.Results 83,69 and 14 chemical components were detected in SLBZS,lacked Platycodonis Radix of SLBZS and Platycodonis Radix,respectively.The result of Venn intersection showed that there was no difference in the types of chemical components between SLBZS and lacked Platycodonis Radix of SLBZS.But the peak area comparison showed significant differences in the contents of cAMP,apigenin,batatasin Ⅲ,oleanolic acid,atractylenolideI and linoleic acid(P＜0.05).Conclusion The meridian inducing medicine Platycodonis Radix can effect the dissolution of certain chemical components in SLBZS,which may be one of the mechanisms of meridian inducing medicine.
Shenling Baizhu SanPlatycodonis Radixmedicine for inducing meridiansUPLC-Q-TOF-MS/MSchemical compositiondissolution
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