首页|The impact of endocrine-disrupting chemicals on stem cells:Mechanisms and implications for human health
The impact of endocrine-disrupting chemicals on stem cells:Mechanisms and implications for human health
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The impact of endocrine-disrupting chemicals on stem cells:Mechanisms and implications for human health
Endocrine-disrupting chemicals(EDCs)are compounds,either natural or man-made,that interfere with the normal functioning of the endocrine system.There is increasing evidence that exposure to EDCs can have profound adverse effects on reproduction,metabolic disor-ders,neurological alterations,and increased risk of hormone-dependent cancer.Stem cells(SCs)are integral to these pathological processes,and it is therefore crucial to understand how EDCs may influence SC functionality.This review examines the literature on different types of EDCs and their effects on various types of SCs,including embryonic,adult,and can-cer SCs.Possible molecular mechanisms through which EDCs may influence the phenotype of SCs are also evaluated.Finally,the possible implications of these effects on human health are discussed.The available literature demonstrates that EDCs can influence the biology of SCs in a variety of ways,including by altering hormonal pathways,DNA damage,epige-netic changes,reactive oxygen species production and alterations in the gene expression patterns.These disruptions may lead to a variety of cell fates and diseases later in adult-hood including increased risk of endocrine disorders,obesity,infertility,reproductive abnor-malities,and cancer.Therefore,the review emphasizes the importance of raising broader awareness regarding the intricate impact of EDCs on human health.
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