首页|Roles of serum uric acid on the association between arsenic exposure and incident metabolic syndrome in an older Chinese population
Roles of serum uric acid on the association between arsenic exposure and incident metabolic syndrome in an older Chinese population
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Roles of serum uric acid on the association between arsenic exposure and incident metabolic syndrome in an older Chinese population
Growing evidences showed that heavy metals exposure may be associated with metabolic diseases.Nevertheless,the mechanism underlying arsenic(As)exposure and metabolic syn-drome(MetS)risk has not been fully elucidated.So we aimed to prospectively investigate the role of serum uric acid(SUA)on the association between blood As exposure and incident MetS.A sample of 1045 older participants in a community in China was analyzed.We deter-mined As at baseline and SUA concentration at follow-up in the Yiwu Elderly Cohort.MetS events were defined according to the criteria of the International Diabetes Federation(IDF).Generalized linear model with log-binominal regression model was applied to estimate the association of As with incident MetS.To investigate the role of SUA in the association be-tween As and MetS,a mediation analysis was conducted.In the fully adjusted log-binominal model,per interquartile range increment of As,the risk of MetS increased 1.25-fold.Com-pared with the lowest quartile of As,the adjusted relative risk(RR)of MetS in the highest quartile was 1.42(95％confidence interval,CI:1.03,2.00).Additionally,blood As was posi-tively associated with SUA,while SUA had significant association with MetS risk.Further mediation analysis demonstrated that the association of As and MetS risk was mediated by SUA,with the proportion of 15.7％.Our study found higher As was remarkably associated with the elevated risk of MetS in the Chinese older adults population.Mediation analysis indicated that SUA might be a mediator in the association between As exposure and MetS.
Department of Public Health,Fourth Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310058,China
Department of Public Health,Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310058,China
Department of Public Health,National Clinical Research Center for Child Health of Children's Hospital,Zhejiang University School of Medicine,Hangzhou 310058,China
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NSTL
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