Trajectory of Sense of Coherence in Nasopharyngeal Carcinoma Patients with Concurrent Chemo-radiotherapy Using A Latent Growth Mixture Model
Objective To investigate the longitudinal development trajectory of sense of coherence during concurrent chemoradiotherapy in patients with nasopharyngeal carcinoma(NPC),and to analyze its influencing factors.Methods From November 2022 to June 2023,225 patients with concurrent radiotherapy and chemotherapy in a tertiary A gener-al hospital in Guangxi province were selected by the convenience sampling method,and the general data questionnaire,M.D.Anderson Symptom Inventory-Head and Neck module,MDASI-HN,and Sense of Coherence scale-13 were used to collect data at the 1st,15th,and 30th radiotherapy sessions.The latent variable growth mixed model was used to identify their development trajectories,and the influencing factors of the trajectories were analyzed by logistic regres-sion.Results There were 3 trajectories of sense of coherence in patients with NPC concurrent chemoradiotherapy,which were the persistent low flat group(20.00％),the continuous decline group(28.00％),and the continuous rise group(52.00％).Logistic regression analysis showed that symptom severity,age,education,place of residence,caregiver and tumor stage were independent influencing factors of sense of coherence in patients with nasopharyngeal carcinoma(all P＜0.05).Conclusions There is group heterogeneity in the sense of coherence in patients with concurrent radio-therapy and chemotherapy,which should be evaluated and intervened based on the change trajectory of the sense of co-herence in patients.
nasopharyngeal carcinomasense of coherencelatent growth mixture modelinfluencing factor
NETL
NSTL
万方数据
维普
