Status Quo of Febrile Neutropenia in Children with Acute Leukemia After Chemotherapy and Its Influencing Factors
Objective To explore status quo of febrile neutropenia(FN)in children with acute leukemia after chemotherapy and its influencing factors,and to provide reference for early prevention,identification and intervention of clinical staff.Methods A total of 801 pediatric patients with acute leukemia treated with chemotherapy in the Department of Pediatric Hematology in a tertiary A pediatric hospital from January to December 2022 were selected by the convience sampling method.The demographic,disease-related,treatment-related data were collected.Logistic regression analysis was used to screen out the risk factors of FN,and receiver operating characteristic(ROC)cure was used to assess the resulting equation.Results The incidence of FN in children with acute leukemia was 3346％.There were significant differences in the occurrence of FN among children with acute leukemia with different personal history,disease history,treatment history,and past history(all P＜0.05).Logistic regression analysis showed that age,oral mucosal integrity damage on the 5th day,disease recurrence,primary chemotherapy,use of cytarabine,and neutropenia on the 5th day were independent influencing factors for FN in children with acute leukemia,and the area under the ROC curve was 0.884.Conclusion The incidence of FN in pediatric patients with acute leukemia is relatively high.Prevention of FN should be emphasized from the first-time chemotherapy,especially in pediatric patients with recurrence,young age,and early neutropenia.At the same time,nurses should pay attention to assessment of oral mucositis,blood routine test,and vital signs,so as to actively prevent and treat oral mucositis and bone marrow suppression.
万方数据
维普
