Impact of Adverse Symptoms on the Quality of Life in Gynecologic Cancer Patients during Chem-otherapy:A Longitudinal Study
Objective To examine the changes in adverse symptoms and their impact on the quality of life in gynecological cancer patients in different stages in chemotherapy.Methods A longitudinal survey was conducted on 3,247 gynecological cancer patients undergoing chemotherapy in a tertiary A hospital in Chengdu from January 2022 to October 2023,who were selected with convenience sampling.Assessments of chemotherapy-induced nausea and vomiting grading,stool characteristics scoring,pain scoring,fatigue scales,Pittsburgh sleep quality index,and cancer functional assessment were used after the lst,3rd,and 5th cycles of chemotherapy.Results Repeated measures ANOVA and chi-square tests revealed that with in-creasing chemotherapy cycles,nausea and vomiting and fatigue intensified(x2=82.187,P＜0.001;F=8.239,P＜0.001),while sleep quality(F=16.876,P＜0.001)and quality of life(QoL)(F=8.39,P＜0.01)deteriorated.There was an increase in abnormal bowel movements(x2=60.354,P＜0.001)and a de-crease in pain severity(F=3.876,P＜0.05).Generalized estimating equation analysis showed that patients with medical insurance had better QoL,whereas those with advanced disease,more pronounced nausea and vomiting,and greater pain and fatigue had worse QoL.Conclusions Gynecological cancer patients experience a variety of adverse symptoms during chemotherapy,with some intensifying over cycles.Medical insurance status,stage of disease,and the severity of nausea and vomiting,pain,and fatigue all significantly affect QoL.
gynecologic cancerchemotherapyadverse symptomquality of lifelongitudinal study
万方数据
维普
