Meta-Analysis of Effectiveness of Heated Humidified High-flow Nasal Cannulae in Preventing Nasal Injury in Premature Infants with Respiratory Distress Syndrome
Objective To systematically evaluate the effectiveness of heated humidified high-flow nasal cannulae(HHHFNC)in preventing nasal injuries in premature infants with respiratory distress syndrome(RDS).Methods Randomized controlled studies on HHHFNC prevention of nasal injuries in premature infants with RDS were searched in PubMed,Embase,VIP,CNKI and other databases.The retrieval timeframe was from the inception to March 2024.Stata16.0 and RevMan 5.3 were used for meta-analysis,and Grade system was used to evaluate the quality of evidence.Results A total of 35 RCTS were retrieved and 3502 subjects were studied.The results of Meta-analysis showed that the experimental group(HHHFNC)had significantly lower incidence of nasal injury[RR=0.28,95％CI(0.23,0.35),P＜0.001]and air leakage[RR=0.30,95％CI(0.18,0.49),P＜0.001]than the control group(other non-invasive ventilation modes).The results of the Grade evidence grading showed that the incidence of nasal injury and the incidence of air leakage were of medium quality.Conclusions The use of HHHFNC can re-duce the incidence of nasal injuries in premature infants with RDS.
万方数据
维普
