Objective To investigate the status quo of treatment burden in patients with CHF and to explore the mediating effect of coping style between social support and treatment burden.Methods A total of 221 patients with CHF from a tertiary A hospital in Guangzhou was selected by convenience sampling and surveyed with multimor-bidity treatment burden questionnaire,social support revalued scale,and medical coping modes questionnaire.Results The total scores of treatment burden and social support in patients with CHF were 14.6(8.3,20.8)and(33.57±6.06),respectively.The sores of confrontation,avoidance and acceptance-resignation were 14.0(11.0,16.0),16.0(15.0,16.0)and 9.0(6.0,11.0).Social support was negatively associated with treatment burden and acceptance-res-ignation,while acceptance-resignation was positively related to treatment burden(P<0.05).Acceptance-resignation played a partial mediating role between social support and treatment burden(effect size:-0.154),with a mediating effect accounting for 34.07%.Conclusions Social support can influence treatment burden by acceptance-resignation.In order to lessen the treatment burden,medical professionals should pay special attention to patients without ade-quate social support,as well as guide them to adopt positive coping style.