Effects of Oridonin on Migration and Invasion of Human Chondrosarcoma SW-1353 Cells
To investigate the effects of oridonin on migration and invasion of human chondrosarcoma cells.In vitro experi-ments,human chondrosarcoma SW-1353 cells were divided into control group being without intervention,1.25,2.50,5.00 μmol/L oridonin groups(1.25,2.50,5.00 μmol/L oridonin)and positive drug group(6 μmol/L adriamycin).Human chondro-sarcoma SW-1353 cells were tested for viability,mobility,invasion ability and epithelial-mesenchymal transition(EMT)expres-sion.The results show that:compared with the control group,SW-1353 cell viability in the 5.00 μmol/L oridonin group and positive drug group significantly decreased(P<0.05).1.25,2.50,5.00 μmol/L oridonin groups and positive drug obviously in-hibted cell migration and invasion in a concentration-dependent manner(P<0.05).The expression of E-cadherin decreased the expression of vimentin and N-cadherin and inhibited EMT process by increasing the expression of E-cadherin protein,and the higher the concentration,the more significant the change was(P<0.05).Lamonidin can significantly inhibit the migration and invasion of human chondrosarcoma SW-1353 cells,or through mediating EMT,which provides a theoretical basis for the bio-logical study of human chondrosarcoma cells.
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