L-methionine is an essential amino acid with a wide range of applications in food,feed,cosmetics and pharmaceu-ticals.Currently,L-methionine is the only essential amino acid that cannot be industrially produced by microbial fermentation.In recent years,the use of metabolic engineering to enhance the yield of L-methionine has received widespread attention from researchers at home and abroad.In this paper,the biosynthetic pathway and regulatory mechanism of L-methionine in Coryne-bacterium glutamicum and Escherichia coli are analysed;three key steps(i.e.,acylation,sulfurylation,and methylation)in the biosynthesis of methionine from hyper-serine are highlighted,and a further outlook on the biosynthesis of L-methionine is pro-posed with a view to providing guidance for the industrial production of L-methionine.
维普
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