EFFECTS OF XIJIAO DIHUANG DECOCTION IN PREVENTING HEAT STROKE IN MICE AND THE CHANGES OF HAEMATOLOGICAL INDEX
In order to investigate the effects of Xijiao Dihuang decoction on the prevention of heat stroke in mice and its changes of haematological index.Thirty mice were randomized to blank group,heat stroke group and intervention group,10 mice in each group.Mice in the intervention group were gavaged with 11.375 g/kg of Xijiao Dihuang decoction for 5 days,and mice in the blank and heat stroke groups were gavaged with equal amounts of saline.And mice were given equal doses of Xijiao Dihuang decoction for gavage 2 h before moulding.The mice in the heat stroke and intervention groups were placed at a constant temperature of 40℃for 60 min,while the mice in the blank group were placed at room temperature to compare the anti-stroke effect of each group.The results showed that the anal temperature of mice in the heatstroke group was significantly increased compared with the blank group(P<0.05),which was significantly decreased in the intervention group compared with the heatstroke group(P<0.05);the levels of blood WBC,Gran#,Lymph#,Mon#,RBC,HGB,HCT,MCV,RDW,MPV,and PDW of mice in the heatstroke group were significantly increased compared with the blank group(P<0.05),which were significantly decreased in the intervention group compared with the heatstroke group(P<0.05),it was reversed for PLT and PCT levels.Compared with the blank group,serum AST,ALT,BUN,CREA,and CK levels were significantly increased in the heatstroke group of mice(P<0.05),which were significantly decreased in the intervention group of mice compared with the heatstroke group(P<0.05).Serum MDA,TNF-α,IL-6 and IL-1β levels were significantly increased in the heatstroke group of mice compared with the blank group(P<0.05),and SOD,GSH-PX and HSP70 were significantly decreased(P<0.05).The serum levels of MDA,TNF-α,IL-6 and IL-1β were significantly decreased(P<0.05)and the levels of HSP70,SOD and GSH-PX were significantly increased(P<0.05)in the intervention group compared with the heatstroke group.These suggests that Xijiao Dihuang decoction can effectively prevent the occurrence of heat stroke diseases,and its mechanism may be related to inhibiting the inflammatory response and increasing the antioxidant level,which may provide a certain theoretical basis for the use of Xijiao Dihuang decoction in the prevention and treatment of heat stroke diseases.
Xijiao Dihuangdecoctionheat strokehaematological index
万方数据
维普
