DESIGN,SYNTHESIS AND ANTIFUNGAL ACTIVITY OF AR-TURMERONE DERIVATIVES
The aim of this paper is to try to find high biological ar-turmerone derivatives.According to the structural characteristics of ar-turmerone,it was modified and its structure was characterized by 1H NMR and 13C NMR;At the same time,the compound solutions of different concentrations were prepared by gradient dilution method,and the prepared solutions were coated on a plate to determine the minimum antifungal concentration of the compound.The results showed that the seven new derivatives(A-G)designed and synthesized showed different degrees of inhibitory effects on Fusarium oxysporum.Among them,the antifungal effects of compounds E and F were the most significant;compounds B,C,D and G had strong antifungal activity;The antifungal effect of compound A was relatively weak.This study can provide certain reference basis for future research and development in the field of ar-turmerone drugs.
万方数据
维普
