In order to explore the effects of cadmium(Cd)and lead(Pb)stress on the seed germination and seedling growth of mulberry and to screen the germplasm resources with high resistance.Zheza-1(ZZ-1)~Zheza-9(ZZ-9)(9 kinds of mulberry hybrid varieties)were used as materials.The indexes of seed germination and seedling growth of mulberry were determined by Cd(0,25,100,400,1 000 mg/L)and Pb(0,250,500,1 000,2 000 mg/L)at different concentrations.The results showed that the mulberry seed germination were not significantly inhibited by Cd and Pb at the low concentrations;but when the single Cd concentrations were more than 100 mg/L,and the single Pb concentrations were more than 250 mg/L,the seed germination index,seed vigor index,hypocotyl and radicle length of 9 mulberry seeds decreased significantly with the increase of heavy metal ion concentration.There were differences in the resistance of 9 varieties to Cd and Pb.Principal component analysis and membership function method were used to comprehensively evaluate the resistance of 9 varieties to Cd and Pb,among which ZZ-6 had the strongest resistance to Cd and Pb,and was expected to be popularized as a planting variety of mulberry in agricultural production to repair the soil contaminated by Cd and Pb.