SCREENING OF HUB GENES CO-EXPRESSED IN PSORIASIS AND MELANOMA AND ANALYSIS OF POTENTIAL COMORBIDITY MECHANISMS
Bioinformatics methods were used to screen the hub genes and analyze the molecular mechanisms co-expressed by psoriasis and melanoma,providing new ideas for follow-up studies.The melanoma gene expression datasets(GSE7553,GSE15605)and psoriasis gene expression datasets(GSE14905,GSE30999)were downloaded from the Gene Expression Omnibus database,and the co-expressed genes were identified and analyzed by GO and KEGG enrichment,and protein-protein interaction networks were constructed to screen the hub genes using the STRING database and Cytoscape software.Subsequently,the hub gene co-expression network was constructed and GO and KEGG enrichment analysis was performed.The screened hub genes were validated using GSE15605 dataset and GSE30999 dataset.Finally,transcription factor regulatory networks were constructed from the hub genes.A total of 10 hub genes were screened in this study:MMP9,COKN1A,ADIPOQ,FEN1,KRT19,DTL,TPX2,TYMS,PCK1,and PIP.GO enrichment analysis showed that the hub genes'functions were mainly related to ultraviolet response,DNA biosynthesis,and photostimulation,etc.,and KEGG enrichment analysis showed that the hub genes were mainly involved in bladder cancer,adipokine signaling pathway,PPAR signaling pathway and other metabolic pathways;RELA and NFKB1 are key transcription factors regulating the hub genes.This study initially reveals the molecular mechanism of the combined pathogenesis of psoriasis and melanoma,and provides a theoretical basis for the idea of"two-disease simultaneous treatment"of psoriasis and melanoma.
psoriasismelanomadifferentially expressed genestranscription factorscombined treatment of psoriasis and melanoma
万方数据
维普
