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基于自适应窗口空间方向衬比方法的血管成像方法研究

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血管可视化在血管疾病、慢性病发展机制研究及诊断治疗等领域中均发挥着重要作用,激光散斑成像技术被广泛应用于血管可视化和血流监测中,而血管成像中存在的各种噪声会降低血管成像质量。为提高深层血管成像质量,通过设计在体实验,对现有的四种空间域衬比方法的血管成像能力及检测血流相对流速的可行性进行探究,并引入对比噪声比对血管可视化能力进行量化评估。研究结果表明,自适应窗口空间方向衬比方法的成像能力优于其他三种空间域衬比方法(空间衬比方法、空间方向衬比方法、自适应窗口衬比方法)。在体实验中自适应窗口空间方向衬比方法能保持高质量、高分辨率的血流测绘能力,从而保留更多微小血管的结构和功能信息,获得更为全面的血流分布图,在深部组织的血流监测方面具有一定优势。
Vascular Imaging Method Based on Adaptive-Window-Space Directional Contrast Method
Vascular visualization is crucial for investigating vascular diseases,the development mechanism of chronic diseases,as well as the related diagnosis and treatment.Meanwhile,laser speckle imaging technology is widely used in vascular visualization and blood-flow monitoring,although the quality of vascular imaging is degraded by the presence of various noises.To improve the quality of deep vascular imaging,this study investigates the capability of vascular imaging and the feasibility of detecting the relative flow rate of blood flow of four existing spatial-domain lining-ratio methods via in vivo experiments.Additionally,a quantitative assessment of the vascular-visualization capability based on the contrast noise ratio is introduced.The results show that the adaptive-window-space directional contrast method offers better imaging than the other three spatial contrast methods(spatial contrast,space directional contrast,and adaptive-window contrast methods).Based on an in vivo experiment,the adaptive-window-space directional contrast method maintains high-quality and high-resolution blood-flow mapping,thus retaining more microvascular structural and functional information.Consequently,more comprehensive blood-flow distribution maps are obtained,thereby facilitating the monitoring of blood flow in deep tissues.

medical opticslaser speckle contrast imagingadaptive window space directional contrastvascular visualization

张博、李德、郭皓宁、王慧泉、王璇、韩广

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天津工业大学生命科学学院,天津 300387

天津工业大学电子与信息工程学院,天津 300387

天津市医疗器械质控与评价技术重点实验室,天津 300387

天津市光电检测技术与系统重点实验室,天津 300387

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医用光学 激光散斑衬比成像 自适应窗口空间方向衬比 血管可视化

2024

激光与光电子学进展
中国科学院上海光学精密机械研究所

激光与光电子学进展

CSTPCD北大核心
影响因子:1.153
ISSN:1006-4125
年,卷(期):2024.61(24)