Research progress of cancer marker detection technology based on PCF-SPR
Cancer is the second leading cause of death worldwide and poses a significant threat to individuals,families and society.Rapid and accurate diagnosis of cancer at an early stage is the primary means of mitigating the le-thal effects of cancer.With the development of biosensors,optical biosensors have received widespread attention.This kind of sensor has the advantages of fast,real-time,accurate,high sensitivity and multiple detection,and has great application potential in the clinical diagnosis and treatment of cancer.This article discusses the advantages and disad-vantages of existing biosensors for cancer marker detection,starting with cancer markers.The working principle of pho-tonic crystal fiber and surface plasmon resonance technology are introduced,and the latest research progress of photon-ic crystal fiber optic fiber sensor based on surface plasmon resonance in early cancer diagnosis is reviewed,combined with the literature reports of PCF-SPR sensors in the field of biology in recent years.Finally,the progress of PCF-SPR biosensors in the field of cancer detection is summarized and prospected.
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