Apremilast,which was developed by Celgene Corporation Company,is the first oral inhibitor of phosphodiesterase 4.It is effective in the treatment of psoriasis by regulating intracellular pro-inflammatory and anti-inflammatory factors and inhibiting the activity of multiple inflammatory factors involved in the pathogenesis of psoriasis.It has been approved by FDA and EMA for the treatment of active psoriatic arthritis(PsA)and plaque psoriasis who are candidates for phototherapy or systemic therapy.The study for its synthesis has important significance.In this article,we conclude its synthetic route,graphic method was used to review and evaluate its synthetic process.
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