Study on Continuous Flow Process for the Synthesis of 2,2,4-Trimethyl-1,3-Pentanediol Monoisobutyrate in a Microchannel Reactor
Compared with the traditional kettle batch production process,the reaction period is long,the yield is limited and other shortcomings,but the advent of the microchannel continuous flow process has significantly upped the ante.This innovative technique has transformed the way this compound is synthesized,boosting its reaction efficiency to remarkable new heights.To achieve this,the microchannel continuous flow processemploys isobutyral as a raw material and taps into the catalytic power of sodium hydroxide and sodium carbonate.This new patternapproach allows researchers to investigate various factors that can influence the synthesis of 2,2,4-trimethyl-1,3-pentanediol monoisobutyrate,including catalyst concentration,dosage,reaction temperature,and residence time.The results of these investigations are nothing short of groundbreaking.Under optimal conditions,which include a 40%concentration of sodium hydroxide,a 14%concentration of sodium carbonate,and a 1:1 ratio of isobutyral to NaOH/Na2CO3,the conversion of isobutyral reaches an impressive rate of 71.59%.This is accompanied by an equally impressive selectivity of 87.96%towards the production of 2,2,4-trimethyl-1,3-pentanediol monoisobutyrate,resulting in a yield of approximately 62.97%.
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