Research Progress of m6A methyltransferase-like3 in colorectal cancer
Colorectal cancer is a common human malignant tumour.N6-methyladenine(m6A)modification is considered to be the major internal epigenetic modification in eukaryotic mRNA,the level of m6A modification is dynamic and reversible.It plays a key determining role in the regulation of splicing,translation and degradation of post-transcriptional mRNA.The m6A methyltransferase plays a cancer-promoting or tumor-suppressing role in tumor development,and it has the potential function to become a therapeu-tic target for malignant tumors.METTL3 is the most important m6A methyltransferase,which several studies have shown to play a role in promoting colorectal cancer through several mechanisms.In this review,we summarized the role and related mechanisms of METTL3 on the initiation and progression of colorectal cancer,for providing a basis for further searching for biomarkers and thera-peutic targets.
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