Common geriatric diseases can interfere with the specificity of p-tau181 and A β 1-42 in diagnosing Alzheimer's disease
Objective In the presence of senile diseases,such as coronary heart disease,cerebral infarction,chronic kidney disease,pulmonary infection,hypertension,diabetes,to explore the phosphorylated tau 181 and β-amyloidprotein 1-42 in the di agnosis of Alzheimer's disease.Methods 30 cases of Alzheimer's disease,senile diseases(351 cases of coronary heart dis-ease,210 cases of cerebral infarction,237 cases of chronic kidney disease,65 cases of pulmonary infection,215 cases of hyper-tension,49 cases of diabetes)and 30 controls of physical examination of phosphorylated tau 181 and beta amyloid protein 1-42 from May 2022 to April 2023.They were divided into Alzheimer's disease group,coronary heart disease group,cerebral infarction group,chronic kidney disease group,pulmonary infection group,hypertension group,diabetes group,and control grouStatistical analysis of the difference between each group,ROC curve analysis of the value of the two indicators in the diagnosis of Alzheimer's disease.Results It showed that the phosphorylation of tau181 in the Alzheimer's disease group(11.8±5.8)was over than that in the coronary heart disease group(16.3±12.4),chronic kidney disease group(16.8±16.3),and pulmonary infec-tion group(21.4±14.0);β-amyloidprotein 1-42 in Alzheimer's disease group(29.2±23.4)was lower than that in chronic kidney dis ease group(56.9±64.4)and lung infection group(53.1±45.1),with statistically significant differences;There was no difference between the two indexes in Alzheimer's disease group and cerebral infarction,hypertension and diabetes groups.The A UC for the combined diagnosis of Alzheimer's disease with two indicators was 0.713(95％CI:0.641～0.785,P＜0.001),with Cut-off values of 19.8 pg/mL and 9.5 pg/mL,respectively.Conclusion When screening Alzheimer's disease according to phosphorylated tau181 and beta amyloid 1-42,elderly patients with non Alzheimer's disease(coronary heart disease,cerebral infarction,chronic kidney disease,pulmonary infection,hypertension,diabetes)may be misdiagnosed as Alzheimer's disease,which will also interfere with the auxiliary diagnosis and interpretation of the results of Alzheimer's disease.It is necessary to exclude Alzheimer's disease in combination with other examinations or assessments to avoid misdiagnosis and mistreatment.This study has certain clinical signifi-cance.
万方数据
维普
