目的 探讨孕中晚期宫内胎儿腰椎3.0 T MRI真稳态进动梯度回波序列（true FISP）矢状位二维定量指标与孕周的关系。 方法 横断面研究。纳入2020年1月—2023年4月青岛大学附属泰安市中心医院行产前MRI检查的59例胎儿的影像资料。孕妇年龄19~41（29.8±5.1）岁，孕周26+1~39+2（32.7±3.7）周。采用3.0 T MR扫描仪对胎儿行MRI检查，采集true FISP图像。在true FISP图像上测量腰椎长轴矢状位二维定量指标（腰椎总长度，L1、L3椎体骨化中心的上下径、前后径）。分析胎儿腰椎二维定量指标与孕周的相关性，并应用线性回归分析获得相应的腰椎生长动力学回归方程。 结果 Y ^ Y ^ None L 1 Y ^ None L 3 Y ^ None L 1 Y ^ None L 3 59例胎儿腰椎总长度及L1和L3椎体骨化中心的上下径、前后径与孕周均呈正相关，差异均有统计学意义（r=0.79~0.95，P值均<0.001）。胎儿腰椎总长度及L1和L3椎体骨化中心的上下径、前后径均随孕周增加呈线性增长，线性回归方程：腰椎总长度=-0.153+0.141 X孕周（R²=0.90，P<0.001），上下径=-0.226+0.023 X孕周（R²=0.77，P<0.001），上下径=-0.264+0.025 X孕周（R²=0.80，P<0.001），前后径=-0.284+0.029 X孕周（R²=0.63，P<0.001），前后径=-0.274+0.030 X孕周（R²=0.63，P<0.001）。 结论 孕中晚期胎儿腰椎3.0 T MRI true FISP序列矢状位二维定量指标与孕周均呈正相关，生长动力学特征符合线性回归模型，可为产前评估胎儿的腰椎发育情况提供参考。 Objective To explore the relationship between the 2D quantitative measurements of the sagittal lumbar spine and gestational age (GA) during middle and late fetal pregnancy on the basis of true fast imaging with steady-state precession (FISP) images of 3.0 T magnetic resonance imaging (MRI). Methods The cross-sectional study was conducted. This study used the imaging data of 59 pregnant women who underwent MRI examinations at the Affiliated Taian City Central Hospital of Qingdao University from January 2020 to April 2023. The women were aged 19-41 (29.8±5.1) years, and GA was 26+1-39+2 (32.7±3.7) weeks. The fetus was examined using a 3.0 T magnetic resonance scanner, and true FISP images were collected. The 2D sagittal position with the long axis of the lumbar spine on the true FISP images was measured (total length of lumbar spine, the superior-inferior and anteroposterior diameters of the ossification centers of the L1 and L3 vertebrae). The correlation between the 2D quantitative indexes of the fetal lumbar spine measurement index and GA was analyzed, and linear regression analysis was performed to obtain the corresponding regression equation for the growth kinetics of the lumbar spine. Results Y ^ Y ^ s u p e r i o r i n f e r i o r d i a m e t e r s o f - L 1 Y ^ s u p e r i o r i n f e r i o r d i a m e t e r s o f - L 3 Y ^ o p o s t e r i o r d i a m e t e r s o f L 1 Y ^ a n t e r o p o s t e r i o r d i a m e t e r s o f L 3 Among the 59 cases, a positive correlation was observed between GA and the length of the fetal lumbar spine and the superior-inferior and anteroposterior diameters of the ossification centers of the L1 and L3 vertebrae. The differences were statistically significant (r = 0.79-0.95, all P values < 0.001). The length of the fetal lumbar spine and the superior-inferior and anteroposterior diameters of the ossification centers of the L 1 and L3 vertebrae exhibited linear growth with increasing GA. The linear regression equations were as follows:total length of lumbar spine = -0.153 + 0.141 XGA, (R2 = 0.90, P < 0.001) = -0.226 + 0.023 XGA, (R2 = 0.77, P < 0.001) = -0.264 + 0.025 XGA, (R2 = 0.80, P < 0.001) = -0.284 + 0.029 XGA, (R2 = 0.63, P < 0.001) and = -0.274 + 0.030 XGA, (R2 = 0.63, P < 0.001). Conclusion On the basis of 3.0 T true FISP MRI, the 2D quantitative measurements on the sagittal lumbar spine are positively correlated with GA during middle and late fetal pregnancy. The growth dynamics characteristics fit a linear regression model, which can provide reference for the prenatal assessment of fetal lumbar spine development.
Imaging observation of the relationship between fetal lumbar spine development and gestational age based on prenatal 3.0 T MRI true FISP sequence
Objective To explore the relationship between the 2D quantitative measurements of the sagittal lumbar spine and gestational age (GA) during middle and late fetal pregnancy on the basis of true fast imaging with steady-state precession (FISP) images of 3.0 T magnetic resonance imaging (MRI). Methods The cross-sectional study was conducted. This study used the imaging data of 59 pregnant women who underwent MRI examinations at the Affiliated Taian City Central Hospital of Qingdao University from January 2020 to April 2023. The women were aged 19-41 (29.8±5.1) years, and GA was 26+1-39+2 (32.7±3.7) weeks. The fetus was examined using a 3.0 T magnetic resonance scanner, and true FISP images were collected. The 2D sagittal position with the long axis of the lumbar spine on the true FISP images was measured (total length of lumbar spine, the superior-inferior and anteroposterior diameters of the ossification centers of the L1 and L3 vertebrae). The correlation between the 2D quantitative indexes of the fetal lumbar spine measurement index and GA was analyzed, and linear regression analysis was performed to obtain the corresponding regression equation for the growth kinetics of the lumbar spine. Results Y ^ Y ^ s u p e r i o r i n f e r i o r d i a m e t e r s o f - L 1 Y ^ s u p e r i o r i n f e r i o r d i a m e t e r s o f - L 3 Y ^ o p o s t e r i o r d i a m e t e r s o f L 1 Y ^ a n t e r o p o s t e r i o r d i a m e t e r s o f L 3 Among the 59 cases, a positive correlation was observed between GA and the length of the fetal lumbar spine and the superior-inferior and anteroposterior diameters of the ossification centers of the L1 and L3 vertebrae. The differences were statistically significant (r = 0.79-0.95, all P values < 0.001). The length of the fetal lumbar spine and the superior-inferior and anteroposterior diameters of the ossification centers of the L 1 and L3 vertebrae exhibited linear growth with increasing GA. The linear regression equations were as follows:total length of lumbar spine = -0.153 + 0.141 XGA, (R2 = 0.90, P < 0.001) = -0.226 + 0.023 XGA, (R2 = 0.77, P < 0.001) = -0.264 + 0.025 XGA, (R2 = 0.80, P < 0.001) = -0.284 + 0.029 XGA, (R2 = 0.63, P < 0.001) and = -0.274 + 0.030 XGA, (R2 = 0.63, P < 0.001). Conclusion On the basis of 3.0 T true FISP MRI, the 2D quantitative measurements on the sagittal lumbar spine are positively correlated with GA during middle and late fetal pregnancy. The growth dynamics characteristics fit a linear regression model, which can provide reference for the prenatal assessment of fetal lumbar spine development.
Fetal developmentLumbar spineMagnetic resonance imagingTrue fast imaging with steady-state precessionPrenatal examination
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