Objective To compare the effects of endotracheal intubation and balloon assisted respiration in pre hospital emergency treatment of cardiac arrest and cardiopulmonary resuscitation.Methods: 78 patients with cardiac arrest admitted to our hospital from April 2020 to April 2021 were selected as the subjects of this study.They were randomly divided into two groups: the observation group and the control group, with n=39.In the control group, endotracheal intubation was used in the pre hospital first aid of cardiopulmonary resuscitation, while in the observation group, balloon was used in the pre hospital first aid of cardiopulmonary resuscitation.The clinical indexes, success rate and satisfaction of cardiopulmonary resuscitation, and cardiac function were compared between the two groups.Results: The blood oxygen saturation 10 minutes after resuscitation in the observation group was higher than that in the control group (P<0.05), and the time to establish ventilation was lower than that in the control group (P<0.05).The success rate and satisfaction of cardiopulmonary resuscitation in the observation group were 97.44% and 94.87%, respectively, and 84.62% and 79.49% in the control group.Compared with the control group, the success rate and satisfaction of cardiopulmonary resuscitation in the observation group were higher (P<0.05).LVEF and 6MWT in the observation group were higher than those in the control group 3 days after resuscitation (P<0.05), and BNP was lower than that in the control group (P<0.05).Conclusion: The application of balloon assisted cardiopulmonary resuscitation in pre hospital emergency treatment of patients with cardiac arrest is better than that of patients with endotracheal intubation in clinical indicators, success rate of resuscitation, satisfaction, etc., which is worth popularizing.