摘要
目的:观察多囊卵巢综合征(PCOS)不孕患者在不同促甲状腺激素(TSH)水平及体质量指数(BMI)下的内分泌代谢特点.方法:选取计划辅助生殖妊娠的PCOS不孕患者共123例,根据TSH2.5mU/L及BMI 24 kg/m2分为TSH＜2.5 mU/L+正常体重组(A组)、TSH＜2.5 mU/L+超重及肥胖组(B组)、TSH≥2.5 mU/L+正常体重组(C组)以及TSH≥2.5 mU/L+超重及肥胖组(D组),比较组间内分泌代谢指标的差异.结果:①TSH、BMI均与胰岛素抵抗指数(HOMA-IR)呈显
Abstract
Objective To observe the endocrine and metabolic characteristics of infertility patients with PCOS under different levels of TSH and BMI. MethodsA total of 123 infertility patients with PCOS who planned assisted reproductive pregnancy were collected. According to the TSH cut-off point of 2.5 mU/L and BMI value of 24 kg/m2 was divided into TSH＜2.5 mU/L+normal weight group (group A), TSH＜2.5mU/L+ overweight and obese group (group B), TSH≥2.5 mU/ L+normal weight group (group C) and TSH≥2.5mU/L+overweight and obese group (group D).The differences of clinical data and endocrine metabolism indexes between groups were compared.Results ① TSH and BMI were significantly positively correlated with HOMA-IR(r=0.270, 0.312, P＜0.05),elevated TSH levels were mainly associated with IFG,increased BMI was mainly associated withIGTand increased TC, LDL-C. ② IR was also present in PCOS infertile patients with TSH＜2.5 mU/ L and normal body weight.ConclusionPCOS infertility patients with normal thyroid function and weight also have IR,OGTT, insulin release test, and lipid profile should be routine screening for all PCOS patients when planningpregnancy.
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