Objective To discuss the application of detail nursing in operating room nursing.METHODS: Ninety patients treated surgically from June 2021 to June 2022 were selected and divided into two groups, using detail nursing in the experimental group and conventional nursing in the control group.RESULTS: Anxiety scores, depression scores, nursing satisfaction rate, quality of care scores, post-surgical complication rate, patient cooperation rate, and quality of life scores were compared between the two groups (P<0.05).The duration of surgery was compared between the two groups (P>0.05). CONCLUSION: The use of detail care in surgically treated patients has important clinical value in reducing postoperative complications, improving the quality of care, relieving negative emotions, and enhancing the patient''s cooperation rate with surgery.