Objective To compare the efficacy of routine blood test and C-reactive protein test in outpatient respiratory tract infection. Methods: The study subjects were selected from January 2022 to October 2022.150 patients with respiratory tract infection confirmed in the hospital outpatient department were selected and included in the observation group; 50 cases of bacterial infection, 50 cases of virus infection and mycoplasma 50 cases of mycoplasma infection; 50 patients who received physical examination in the hospital at the same time were included in the control group. Results: The positive rate of combined diagnosis was significantly higher than that of single blood routine and single CRP index (P < 0.05). The white blood cell count, neutrophil count, monocyte percentage, monocyte count and CRP index in observation group were higher than those in control group (P < 0.05). Conclusion: The diagnostic effect of C-reactive protein in outpatient respiratory tract infection is obviously better than that of blood routine diagnosis, and the accuracy of disease diagnosis is high, so it is recommended for clinical detection of disease.