摘要
目的:分析对喹诺酮类抗菌药物实施药学干预对于其临床用药合理性的影响.方法:对全院进行为期三个月的喹诺酮类抗菌药物临床应用的药学干预,分别选取进行药学干预前后喹诺酮类抗菌药物治疗患者50例,分为一般组和研析组.对比两组不良反应(皮肤损伤、全身反应、胃肠道反应)发生率、不合理用药(用法不合理、联合用药不合理、用量不合理、溶剂不合理、疗程不合理、用药禁忌、年龄不适宜)率及治疗前后患者炎症因子(WBC、TNF-α、PCT)水平.结果:治疗前,研析组炎症因子(WBC、TNF-α、PCT)水平与一般组对比,两组近似(
Abstract
Objective To analyze the influence of pharmaceutical intervention on the rationality of clinical use of quinolones. Methods: The pharmaceutical intervention of clinical application of quinolones antibiotics was carried out in the whole hospital for three months. Fifty patients with quinolones before and after the pharmaceutical intervention were selected and divided into general group and research group. The incidence of adverse reactions (skin injury, systemic reaction, gastrointestinal reaction), irrational drug use (unreasonable use, unreasonable combination of drugs, unreasonable dosage, unreasonable solvent, unreasonable course of treatment, contraindication of drug use, inappropriate age), and inflammatory factors (WBC, TNF) of patients before and after treatment were compared between the two groups-α、PCT) level. Results: Before treatment, the inflammatory factors (WBC, TNF) in the study group-α、PCT) level was similar between the two groups (P＞0.05). After treatment, the inflammatory factors (WBC, TNF) in the research and analysis group-α、The level of PCT) was lower than that of the general group, with statistical significance (P, There was statistical significance (P＜0.05). Conclusion: Pharmaceutical intervention can promote the rational use of quinolones and reduce adverse reactions in patients.
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