Objective To observe the clinical efficacy of nursing intervention in improving the lifestyles of patients with cardiovascular disease and those at high risk of cardiovascular disease. METHODS: 88 patients with cardiovascular disease and patients with high-risk groups of cardiovascular disease admitted to our hospital from April 2020 to April 2022 were the subjects of this study, and the patients were divided into the control group (44 cases: conventional nursing intervention) and the experimental group(44 cases: anticipatory nursing intervention) according to the different modes of nursing intervention, and the nursing intervention effects of the two groups were compared. RESULTS: Self-care ability [ESCA scale (151.25±3.46) points], cardiac function indexes [left heart ejection fraction (67.23±3.43)%, left ventricular isovolumic diastolic time (82.42±2.11) ms, left ventricular beat volume (75.21±2.43) mL] and the incidence of cardiovascular events in the experimental group after 6 months of follow-up ( 6.82%), quality of life [total CQQC questionnaire score (141.21±3.48)] and other clinical indicators were better than the control group, and the data were significantly different (P<0.05). Conclusion:The effect of different nursing interventions for patients with cardiovascular disease and those at high risk of cardiovascular disease can have different effects on lifestyle, and the effect of anticipatory nursing intervention is significantly better than that of conventional nursing intervention.