Objective To explore the influence of rapid rehabilitation nursing service mode on satisfaction, pain and disease cognition of patients with liver cancer undergoing intervention. Methods: 84 patients with liver cancer who were treated in our hospital from January 2020 to January 2021 were selected for the study. They were randomly divided into the observation group and the control group, with 42 patients in each group. The control group was given routine intervention, while the observation group was given rapid rehabilitation nursing measures based on the care of the control group. The nursing satisfaction, disease cognition and pain score of the two groups were compared. Results: Compared with the control group, the eligible rate of postoperative disease cognition of the observation group was higher (P<0.05); The pain score of the observation group was lower than that of the control group (P; The satisfaction of 97.56% in the observation group was better than that of 92.68% in the control group (P<0.05). Conclusion: The rapid rehabilitation nursing mode has a significant nursing effect for the interventional treatment of liver cancer, which can further improve the patients'' awareness of the disease, relieve postoperative pain, and accelerate postoperative rehabilitation. It is worth popularizing and applying in clinical practice.