摘要
目的:针对不同胰岛素及联合用药方案在糖尿病疾病治疗中的临床运用效果情况展开观察与探析.方法:将我院自2021年6月到2022年5月所接诊的90例糖尿病患者作为观察主体,按随机数字表法将其分作参照组与联合组(各有45例),参照组采取门冬胰岛素30治疗,联合组采取甘精胰岛素与西格列汀联合治疗.对上述两组患者的治疗总有效率、血糖指标变化、胰岛素指标变化等情况加以观察与对比.结果:联合组治疗后总有效率(95.56％)比参照组(80.00％)患者高,存在显著性差异(χ2=5.075,P ＜ 0.05);两组治疗前F
Abstract
Objective To observe and analyze the clinical application effect of different insulin and combined medication schemes in the treatment of diabetes.Methods 90 patients with diabetes admitted by our hospital from June 2021 to May 2022 were taken as the subject of observation,and they were divided into the reference group and the combination group (45 cases each) according to the random number table. The reference group was treated with insulin aspart 30,and the combination group was treated with insulin glargine and sitagliptin. Observe and compare the total effective rate,changes of blood glucose index and insulin index of the above two groups of patients.Results The total effective rate of the combined group (95.56％) was higher than that of the control group (80.00％),with a significant difference(χ2=5.075,P＜0.05),There was no significant difference in FPG,2hPG,HbAlc and other indicators between the two groups before treatment (P＞0.05);After treatment,FPG,2hPG,HbAlc and other indicators in the combined group were not only lower than those before treatment in this group,but also lower than those after treatment in the reference group,with significant differences (P＜0.05);HOMA-IR and HOMA before treatment-β There was no significant difference in the indexes (P＞0.05);After treatment,the HOMA-IR level of patients in the combined group was lower than that before treatment in this group and after treatment in the reference group,while HOMA after treatment-β The level was higher than that before treatment in this group and after treatment in the reference group (P＜0.05).Conclusion The combined treatment of insulin glargine and sitagliptin for patients with diabetes has a good effect. It can improve the blood sugar level of patients,improve insulin function,and reduce the occurrence of adverse reactions. It is worth vigorously promoting and plying in clinical practice.
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