摘要
目的:探究分析阿替普酶静脉溶栓治疗对急性脑梗死患者神经功能及颅内血流动力学的改善作用.方法:选择2020年1月--2021年1月我院收治急性脑梗死患者110例,按照随机数字表方式分为对照组(常规抗血小板等治疗,n=55例)和研究组(对照组基础上给予阿替普酶静脉溶栓治疗,n=55例),比较两组临床治疗效果,并采用NIHSS量表评估治疗后各时间段的神经功能,另检测患者治疗前后的颅内血流动力学指标.结果:研究组治疗总有效率为94.00％,较对照组要高,P＜ 0.05;研究组治疗后3d、7d、14d及28d的NI
Abstract
Objective To explore and analyze the improvement of neurological function and intracranial hemodynamics in patients with acute cerebral infarction after intravenous thrombolysis with alteplase. Methods: A total of 110 patients with acute cerebral infarction admitted to our hospital from January 2020 to January 2021 were randomly divided into a control group (conventional antiplatelet therapy,etc.,n=55 cases) and a research group (alteplase intravenous thrombolysis treatment was given on the basis of the control group,n=55 cases). The clinical treatment effects of the two groups were compared. The neurological function in each time period after treatment was assessed by NIHSS scale,and the intracranial hemodynamic indexes of patients before and after treatment were also measured. Results The total effective rate of treatment group was 94.00％,which was higher than that of the control group (P＜0.05). The NIHSS scores of the treatment group on the 3rd,7th,14th and 28th day after treatment were (11.28±1.41),(8.60±1.04),(6.63±0.87) and (5.32±0.64),respectively,which were lower than those of the control group in various periods (P＜0.05). Besides,the levels of Vp,Vm and Vd in the treatment group were (66.63±6.67),(50.91±5.12) and (51.76±5.28)cm/s/ s,respectively,which were higher than those in the control group (P＜0.05). Conclusion: Patients with acute cerebral infarction using alteplase intravenous thrombolysis treatment effect is reliable,can significantly reduce the patient''s neurological damage,improve intracranial hemodynamics,is worth promoting.
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