Objective To analyze the effect of thermal insulation nursing in the operating room on postoperative coagulation function and hypothermia in patients with femoral fracture.Methods From March 2020 to June 2021,70 patients with femoral fracture were randomly divided into the observation group and the control group,with an average of 35 cases. They were treated with thermal insulation nursing in the operating room and routine nursing intervention respectively,and the effects were compared. Results The body temperature and coagulation function of the observation group were better than those of the control group,and the difference was statistically significant (P<0.05). Conclusion Intervention of patients with femoral fracture through thermal insulation nursing in the operating room can effectively reduce the incidence of postoperative hypothermia,maintain constant body temperature and good blood coagulation function,which is worth recommending.