Objective To study and analyze the effects of cord blood mesenchymal stem cells transplantation on neural function and apoptosis in rats with cerebral infarction.Methods: Twenty healthy male SD rats of clean grade were selected and divided into the control group (n=10) and the transplantation group (n=10).The model of cerebral infarction was made by the method of internal carotid artery thread embolism.Cord blood mesenchymal stem cells were transplanted into the transplantation group on the first day and the fourth day of modeling.The neural function and the number of apoptosis were compared between the two groups on the first day, the seventh day and the fourteenth day of transplantation.Results: There was no significant difference in nerve function scores between the control group and the transplantation group at 0 d after transplantation (P＞0.05).The nerve function scores in the transplantation group were lower than those in the control group at 7 d and 14 d after transplantation (P＜0.05).Compared with the transplantation group 14 days after transplantation, the number of neuronal apoptosis in the brain tissue of the transplantation group was significantly less (P＜0.05).Conclusion: The transplantation of umbilical cord blood mesenchymal stem cells can play an active role in improving neural function and reducing apoptosis in rats with cerebral infarction.
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